Protocol Library · IRB Protocol PPRN-001-2025
Every protocol. One source of truth.

Searchable, evidence-graded clinical protocols for peptide therapy, hormone optimization, regenerative medicine, and metabolic health. IRB-reviewed. Physician-approved.

Reconstitution standard: All protocols use insulin syringe unit-based dosing. We standardize on 3mL bacteriostatic water (bac water) wherever possible — clean math, hard to mess up. Formula: vial mg ÷ mL = mg/mL concentration. Target dose ÷ concentration × 100 = units to draw.
Nasal delivery: Selank, Semax, Oxytocin, and PT-141 can all be administered intranasally. CNS delivery is faster; systemic effects vary by compound.
Evidence ratings: ★★★★ FDA-approved/strong RCTs · ★★★☆ Multiple clinical studies · ★★☆☆ Emerging evidence · ★☆☆☆ Preclinical only
Reconstitution walkthrough · 3mL standard Watch Video Guide →
No protocols match your search.
Repair & Recovery
ARA-290 (Cibinetide)
IRBIn Stock · 110
Vial
10mg
Bac Water
2mL
Dose
4mg SQ daily
Duration
4–8 weeks
Reconstitution
10mg + 2mL = 5mg/mL · 4mg = 80 units
Mechanism & Evidence
Erythropoietin-derived tissue-protective peptide. Activates innate repair receptor (IRR) without stimulating erythropoiesis. Phase 2 clinical trial: significant improvement in small fiber neuropathy in sarcoidosis patients. Promotes nerve fiber regeneration and reduces neuroinflammation.Brines et al., Mol Med (2014) · Nieuwenhuis et al., Mol Med (2016)
Provider Notes
Go-to for diabetic neuropathy, chemo-induced peripheral neuropathy, and small fiber neuropathy. Pairs with NAD+ for mitochondrial support in neuropathy protocols.
Order from Peptide Pure →
BPC-157
IRBIn Stock · 118
★★☆☆
Vial
10mg
Bac Water
3mL
Dose
250mcg–1mg SQ daily
Route
SQ near site or abdominal · Oral 500mcg 2x/day for GI
Reconstitution — 3mL Standard
10mg + 3mL bac water = 3.33mg/mL
250mcg ≈ 7.5 units · 500mcg ≈ 15 units · 1mg ≈ 30 units
Most forgiving peptide in the formulary. Virtually no side effects at any dose studied.
Mechanism & Evidence
Body Protection Compound-157. 15-amino-acid fragment of human gastric BPC. Promotes angiogenesis (VEGF/NO), tendon-to-bone healing, endothelial protection, and GI mucosal repair. 100+ preclinical studies. No published adverse events at any studied dose. Critical note: BPC-157 lacks FDA approval but carries one of the largest clinical datasets of any research peptide — compliant practitioners will have a clear path forward as reclassification proceeds.Sikiric et al., J Physiol Pharmacol (2018) · Gwyer et al., Growth Factors (2019) · Seiwerth et al., Curr Pharm Des (2018)
⚠ Monitor mood during use. New onset depression/anxiety warrants dose reduction or discontinuation. Bidirectional coagulation effect — caution in patients on anticoagulants.
Provider Notes
Inject SQ near injury site for targeted repair; abdominal for systemic/gut. Oral 500mcg 2x/day for IBD/SIBO. Pairs with TB-500 — see Wolverine. Avoid NSAIDs during cycle (blunts angiogenesis). Word-of-mouth driver for shoulder, knee, and gut repair patients.
Order from Peptide Pure →Reconstitution Video
BPC-157 / TB-500 — Wolverine Stack
IRBIn Stock · 70
★★☆☆
Vial
20mg (10/10)
Bac Water
3mL
Dose
20–50 units SQ daily
Route
Near injury or abdominal
Reconstitution — 3mL Standard
20mg (10+10) + 3mL = 6.67mg/mL
Standard: 20 units daily · Acute injury: 30–50 units near site
Hard to mess up. Our 10/10 blend is the correct 1:1 ratio.
Why the Combo Works
The gold standard repair stack. BPC-157 drives local tissue repair via VEGF/angiogenesis. TB-500 drives systemic cell migration via actin upregulation. Together: local + systemic repair simultaneously. No published contraindications at any studied dose.Sikiric et al., J Physiol Pharmacol (2018) · Goldstein et al., Expert Opin Biol Ther (2012)
Provider Notes
Your workhorse repair protocol. Consistent patient-reported outcomes: shoulder, knee, Achilles, gut. Word-of-mouth referrals from this protocol alone are significant. Acute injury (post-surgical, torn rotator cuff): 30–50 units near site. Maintenance: 20 units daily.
Order from Peptide Pure →Reconstitution Video
MGF (Mechano Growth Factor)
IRBNEW SKU — On Order
★★☆☆
Vial
5mg
Bac Water
2mL
Dose
200mcg SQ post-exercise
Timing
Within 30 min post-resistance training
Reconstitution
5mg + 2mL = 2.5mg/mL · 200mcg = 8 units
Inject near trained muscle group post-exercise.
Mechanism & Evidence
IGF-1 splice variant expressed in response to mechanical loading. Activates satellite cells (muscle stem cells) for repair and hypertrophy. Short half-life — must be injected near target muscle post-training. Preclinical data shows significant muscle regeneration in aging and injury models.Yang & Goldspink, FEBS Lett (2002) · Philippou et al., Mol Biotechnol (2007)
Provider Notes
Best in post-surgical muscle atrophy, sarcopenia, and serious athletes wanting accelerated hypertrophy. Inject near the muscle worked. Short half-life limits systemic effects. NEW SKU — confirm supplier and pricing before prescribing.
Order from Peptide Pure →
TB-500 (Thymosin Beta-4)
IRBIn Stock · 42
★★☆☆
Vial
10mg
Bac Water
2mL
Dose
2.5–5mg SQ 2x/wk
Cycle
Loading 4–6 wks → 2.5mg/wk maintenance
Reconstitution
10mg + 2mL = 5mg/mL · 2.5mg = 50 units · 5mg = 100 units (full syringe)
Inject away from injury — works systemically regardless of site.
Mechanism & Evidence
Thymosin Beta-4. 43-amino-acid peptide present in all human cells. Upregulates actin — cells migrate faster to injury sites. Cardiac repair, corneal healing, dermal wound repair, hair growth. Systemic cardioprotective and neuroprotective effects at standard doses.Goldstein et al., Expert Opin Biol Ther (2012) · Sosne et al., Ann N Y Acad Sci (2010)
Provider Notes
Pair with BPC-157 for the Wolverine combo. Unlike BPC, TB-500 works systemically from any injection site. Loading: 5mg 2x/week × 4–6 weeks. Maintenance: 2.5mg once weekly.
Order from Peptide Pure →
Hormone Optimization
HCG (Human Chorionic Gonadotropin)
RxIn Stock · 91
Vial
10,000 IU
Bac Water
2mL
Dose
500 IU SQ 2x/wk
Use
Fertility preservation on TRT
Reconstitution
10,000 IU + 2mL = 5,000 IU/mL · 500 IU = 10 units · 1,000 IU = 20 units
Refrigerate after reconstitution. Use within 30 days.
Mechanism & Evidence
LH analog. Stimulates Leydig cell testosterone production, maintains spermatogenesis and testicular volume on TRT. Non-negotiable for TRT patients wanting to preserve fertility or testicular size.
Provider Notes
Standard: 500 IU 2x/week. Higher doses (1,000 IU 2x/wk) — watch E2 conversion. Always pair with AI or SERM if estradiol climbs. Include in every TRT protocol for patients who haven't had a vasectomy.
Order from Peptide Pure →
HGH (Human Growth Hormone)
FDA-ApprovedRxLow · 16 (10IU)
★★★★
Vials
10 IU · 15 IU
Bac Water
1mL per 10 IU
Dose
1–3 IU SQ daily (anti-aging) · Up to 6 IU (clinical)
Timing
Pre-sleep or AM fasted
Reconstitution
10 IU + 1mL = 10 IU/mL · 1 IU = 10 units · 2 IU = 20 units · 3 IU = 30 units
Reconstitute gently — swirl, do not shake. Refrigerate. Use within 3–5 days reconstituted.
Mechanism & Evidence
Recombinant human growth hormone. FDA-approved for GH deficiency, Turner syndrome, Prader-Willi, CKD, and HIV wasting. Stimulates IGF-1 production, protein synthesis, lipolysis, and lean mass accretion. ONZEN generally prefers GH secretagogues (CJC/Ipamorelin, Tesamorelin) for most patients — they maintain pulsatility and don't suppress endogenous production. Exogenous HGH reserved for confirmed GH deficiency or specific clinical indication.
⚠ Exogenous HGH suppresses endogenous GH pulsatility and can cause insulin resistance, fluid retention, carpal tunnel, and joint pain at higher doses. Monitor IGF-1, fasting glucose, and HbA1c. Contraindicated in active malignancy.
Provider Notes
Most patients are better served with CJC/Ipamorelin or Tesamorelin. Reserve exogenous HGH for confirmed GH deficiency by IGF-1 + stimulation testing. When used: start at 1 IU/day, monitor IGF-1 monthly, titrate slowly.
Order from Peptide Pure →
Kisspeptin
IRBNEW SKU — On Order
★★★☆
Vial
10mg
Bac Water
2mL
Dose
50–100mcg SQ 1–2x/day
Duration
8–12 weeks
Reconstitution
10mg + 2mL = 5mg/mL · 50mcg = 1 unit · 100mcg = 2 units
Mechanism & Evidence
Master regulator of the HPG axis — activates GnRH neurons via GPR54 receptor. Drives pulsatile LH and FSH release, restoring endogenous testosterone production. Human clinical data shows significant LH/FSH elevation and testosterone restoration in hypogonadal men without suppressing spermatogenesis. Also under investigation for female fertility and libido.Dhillo et al., J Clin Endocrinol Metab (2005) · Jayasena et al., Clin Endocrinol (2014)
Provider Notes
Emerging alternative to enclomiphene for hypogonadism without fertility impairment. Works upstream of the HPG axis — more physiologic than SERMs. NEW SKU — confirm supplier and pricing before prescribing. Monitor LH, FSH, Total T, and Free T at 4 and 8 weeks.
Order from Peptide Pure →
TRT + Enclomiphene Protocol
RxIRB
Testosterone
100–200mg/wk IM or SQ
Enclomiphene
12.5–25mg PO daily
Boron
10mg PO daily
DHEA
25–50mg PO daily
Lab Monitoring Protocol
Baseline: Total T, Free T, SHBG, E2 (sensitive), PSA, CBC, CMP, LH, FSH
8-week recheck: Total T, Free T, E2, Hematocrit (target <54%)
Annual: Full panel + DRE, DEXA, lipids, thyroid
SHBG elevated → add Boron 10mg QD (SHBG suppression +25–30% free T). DHEA supports adrenal precursor pool. High SHBG → also check TSH and LFTs.
Mechanism & Evidence
Exogenous T + SERM + SHBG suppression + precursor support. Enclomiphene (pure trans-isomer of clomiphene) stimulates LH/FSH without estrogenic side effects — preserving fertility on TRT. Boron chelates SHBG. DHEA maintains adrenal androgen and estrogen precursor pool. Boron 10mg QD shown to increase free T by 25–30% in clinical data.Wiehle et al., Andrology (2014) · Naghii et al., J Trace Elem Med Biol (2011)
SHERPA Output Example
Total T 287 [LOW] · Free T 6.2 [LOW] · SHBG 68 [HIGH]
→ TRT + Enclomiphene + Boron 10mg QD + DHEA 25mg QD
→ Recheck Total T, Free T, E2, Hematocrit at 8 weeks
→ SHBG elevation: rule out hypothyroidism (TSH) and hepatic upregulation (LFTs)
Order from Peptide Pure →Enroll Patient →Run in SHERPA →
Weight Loss & Metabolic
5-Amino-1MQ
IRBEmerging
★★☆☆
Form
Oral capsule
Dose
50–150mg daily with food
Cycle
8–12 week blocks
Route
Oral only
Mechanism & Evidence
NNMT (nicotinamide N-methyltransferase) inhibitor. NNMT consumes SAM and NAD+ — blocking it boosts both, shifting metabolism toward fat oxidation without stimulant effects. Activates fat cell differentiation pathways in reverse, promoting lipolysis. Excellent pairing with NAD+ IV protocols.Kannt et al., Sci Rep (2018) · Brachs et al., Mol Metab (2019)
Provider Notes
Best as adjunct to GLP-1 or GH secretagogue protocols. Pairs with NAD+ and MOTS-c for comprehensive metabolic optimization. Monitor liver enzymes at 8 weeks with long-term use. Limited human data — use with informed consent and IRB documentation.
Order from Peptide Pure →Via Peptide Buzz →
AOD-9604
IRBIn Stock · 59
★★☆☆
Vial
5mg
Bac Water
2mL
Dose
250–500mcg SQ daily
Timing
Fasted AM · 12-wk on, 4-wk off
Reconstitution
5mg + 2mL = 2.5mg/mL · 250mcg = 10 units · 500mcg = 20 units
Mechanism & Evidence
C-terminal fragment of HGH (176-191). Isolated lipolytic activity of GH without IGF-1 stimulation or glucose perturbation. Stimulates lipolysis, inhibits lipogenesis. Phase 3 data: significant visceral and subcutaneous fat reduction.Heffernan et al., J Endocrinol (2001) · Stier et al., Obes Res (2004)
Provider Notes
Adjunct to GLP-1 protocols or standalone for patients who prefer daily SQ over weekly injections. Inject abdomen fasted. Pairs with MOTS-c and Tesamorelin for a metabolic triple-stack.
Order from Peptide Pure →
Retatrutide
RxPREFERRED GLP-110mg: On Order
★★★☆
Vials
10mg · 15mg · 20mg · 30mg · 60mg
Bac Water
3mL (use the 30mg vial)
Dose
1–4mg SQ weekly
Titration
1mg ×4wk → 2mg → 3mg → 4mg max
Reconstitution — Always Use the 30mg Vial
30mg + 3mL = 10mg/mL — cleanest math in the formulary
10 units = 1mg · 20 units = 2mg · 30 units = 3mg · 40 units = 4mg
We carry 5 vial sizes. ALWAYS read the label before reconstituting.
⚠ CRITICAL: We carry 10mg, 15mg, 20mg, 30mg, and 60mg vials. Never assume. Confirm vial strength with the patient at every dispensing. Wrong vial = dramatically wrong dose.
Mechanism & Evidence
Triple agonist: GLP-1 + GIP + Glucagon receptor. Phase 2 (Eli Lilly): 24.2% body weight loss at 48 weeks at 12mg — highest weight loss ever recorded in an obesity trial. Glucagon receptor activation provides thermogenic fat burning and hepatic steatosis improvement that dual agonists lack entirely.Jastreboff et al., NEJM (2023) · Rosenstock et al., Lancet (2023)
Provider Notes
Our preferred GLP-1 for most patients. The glucagon component adds fat-burning and liver benefit beyond tirzepatide. Start 1mg, titrate every 4 weeks. Most patients settle at 2–3mg. Pair BPC-157 oral 500mcg 2x/day during titration for GI side effect management.
Order from Peptide Pure →Run in SHERPA →
Semaglutide
FDA-ApprovedRx
★★★★
Dose Range
0.25mg → 2.4mg weekly
Titration
0.25mg ×4wk → 0.5 → 1.0 → 1.7 → 2.4
Route
SQ weekly · Oral available (Rybelsus)
Duration
Continuous (no cycling)
Mechanism & Evidence
GLP-1 receptor agonist. FDA-approved (Ozempic/Wegovy). SUSTAIN/STEP trials: 15–17% body weight loss. Cardiovascular benefit in SUSTAIN-6. Strong evidence base and regulatory standing. Weaker than tirzepatide or retatrutide but often the right choice for regulatory defensibility and insurance pathway.Wilding et al., NEJM (2021) · Marso et al., NEJM (2016)
Provider Notes
MUST pair with resistance training and high protein to prevent muscle loss. Add BPC-157 oral 500mcg 2x/day during titration to manage GI side effects. Tesamorelin adjunct for visceral fat. MOTS-c for metabolic optimization.
Order from Peptide Pure →
Tirzepatide
FDA-ApprovedRxIn Stock · 30mg: 230
★★★★
Vials
10mg · 15mg · 30mg · 70mg
Bac Water
3mL (for 30mg)
Dose
2.5mg → up to 15mg weekly
Titration
2.5mg ×4wk → 5 → 7.5 → 10 → 15
Reconstitution
30mg + 3mL = 10mg/mL · 25u = 2.5mg · 50u = 5mg · 75u = 7.5mg · 100u = 10mg
Mechanism & Evidence
Dual GLP-1/GIP agonist. FDA-approved (Mounjaro/Zepbound). SURMOUNT-1: 22.5% body weight loss at 72 weeks, superior to semaglutide head-to-head. A1C reduction 2.4% in T2DM. The regulatory advantage: FDA approval gives you the strongest compliance position of any GLP-1 agent.Jastreboff et al., NEJM (2022) · Frías et al., NEJM (2021)
Provider Notes
We prefer retatrutide for most patients; tirzepatide has the regulatory + insurance advantage. Minimum 4 weeks per dose step — nausea is the #1 discontinuation reason, slow titration solves it. Stack BPC-157 oral for GI protection.
Order from Peptide Pure →
Growth Hormone Secretagogues
CJC-1295 / Ipamorelin
IRBIn Stock · 189
★★☆☆
Vial
10mg (5/5)
Bac Water
2mL
Dose
200–300mcg SQ bedtime
Cycle
5 on / 2 off · 12–16 weeks
Reconstitution
10mg (5+5) + 2mL = 5mg/mL · 200mcg = 4 units · 300mcg = 6 units
Inject bedtime, empty stomach (no food 2 hours prior). Synergizes with natural nocturnal GH pulse.
Mechanism & Evidence
GHRH analog + ghrelin receptor agonist. CJC-1295 extends GH release duration. Ipamorelin triggers GH pulse without raising cortisol or prolactin — the key advantage over GHRP-2 and GHRP-6. Together they amplify natural GH pulsatility without suppressing endogenous production. Tesamorelin is FDA-approved with identical mechanism.Ionescu & Bhatt, Mod Trends Pharmacopsychiatry (2010) · Raun et al., Endocrinology (2008)
Provider Notes
5 days on, 2 days off to prevent receptor desensitization. Body composition changes at 8–12 weeks. Monitor IGF-1 quarterly. Patients consistently report improved sleep quality within 2–3 weeks. Our 5/5 blend is correctly balanced.
Order from Peptide Pure →
GHRP-2
IRBAdvanced
★★☆☆
Dose
100–300mcg SQ 1–3x/day
Timing
Empty stomach, bedtime preferred
Cycle
12 weeks on / 4 off
Start
100mcg to assess tolerance
Mechanism & Evidence
Strongest GH pulse of any GHRP via ghrelin receptor. Also significantly raises cortisol and prolactin — the main limitation. Largely replaced by Ipamorelin in modern protocols due to cleaner side effect profile. Use when maximum GH pulse is the priority and cortisol/prolactin elevation is acceptable.
⚠ Elevates cortisol and prolactin significantly. Not appropriate for patients with cortisol dysregulation, anxiety, or prolactinoma. Water retention and intense hunger common.
Provider Notes
Generally replaced by Ipamorelin in our protocols. Reserve for cases where maximum GH pulse is needed. Combine with CJC-1295 (no-DAC).
Order from Peptide Pure →
GHRP-6
IRBLegacy
★★☆☆
Dose
100–300mcg SQ 1–3x/day
Indication
Cachexia, underweight, appetite
Timing
Pre-meal at 100mcg for appetite
Cycle
12 weeks
Mechanism & Evidence
First-gen GHRP. Intense appetite stimulation — useful therapeutically for cachexia, wasting, and underweight patients. Largely replaced by Ipamorelin for standard GH protocols. The intense hunger is unmanageable for most patients outside of intentional use cases.
Provider Notes
Niche use: intentional appetite stimulation in cancer cachexia, post-surgical recovery, elderly wasting. Pair with BPC-157 for GI + appetite in wasting patients. Otherwise use Ipamorelin.
Order from Peptide Pure →
IGF-LR3
IRBLow · 20
★★☆☆
Vial
1mg
Bac Water
1mL
Dose
20–100mcg SQ post-exercise
Cycle
4 weeks on / 4 off
Reconstitution
1mg + 1mL = 1mg/mL (1,000mcg/mL) · 20mcg = 2 units · 50mcg = 5 units · 100mcg = 10 units
Mechanism & Evidence
Long R3 variant of IGF-1. 2–3x longer half-life than native IGF-1 due to reduced IGFBP binding. Drives satellite cell activation, muscle protein synthesis, and nitrogen retention. Post-exercise injection maximizes anabolic window. More potent than native IGF-1 at equivalent doses.
⚠ Monitor fasting glucose — IGF-1 activity can cause hypoglycemia at higher doses. Contraindicated in active malignancy. Short cycle lengths to prevent receptor desensitization and minimize cancer risk concerns.
Provider Notes
Best for serious athletes, post-surgical muscle recovery, and sarcopenia. Inject near trained muscle group post-exercise. Short cycles — 4 weeks max, equal time off.
Order from Peptide Pure →
Sermorelin
IRBEntry-Level GHS
★★★☆
Dose
200–500mcg SQ nightly
Cycle
3–6 months on / 1 month off
Timing
Bedtime, empty stomach
Profile
Gentlest, most physiologic GHS
Mechanism & Evidence
Bioidentical GHRH (1-29) fragment. The gateway GH peptide — safest, most physiologic. Was FDA-approved (Geref); withdrawn 2008 for commercial reasons, not safety. Better tolerated than CJC-1295 in sensitive patients. Can be used continuously at lower doses (200mcg) long-term.Walker et al., J Clin Endocrinol Metab (1995) · Vittone et al., J Clin Endocrinol Metab (1997)
Provider Notes
Best entry-level GHS for older patients or those who don't tolerate CJC/Ipamorelin. Combine with Ipamorelin for synergistic GH pulse. Add BPC-157/TB-500 in recovery protocols. Very well tolerated — injection site irritation and occasional headache are the main side effects.
Order from Peptide Pure →
Tesamorelin
FDA-ApprovedIRBIn Stock · 40
★★★★
Vial
10mg
Bac Water
2mL
Dose
2mg SQ daily into abdomen
Duration
12–26 weeks (VAT returns on discontinuation)
Reconstitution
10mg + 2mL = 5mg/mL · 2mg = 40 units
Mechanism & Evidence
FDA-approved GHRH analog (Egrifta). Only FDA-approved body composition GH peptide. Reduces visceral adipose tissue by 18% at 26 weeks. Increases GH and IGF-1 without suppressing endogenous production. Cognitive benefits under investigation for Alzheimer's prevention.Falutz et al., NEJM (2007) · Stanley et al., J Clin Endocrinol Metab (2015)
Provider Notes
Strongest regulatory position of any GHS — FDA approval gives you a clear compliance path for off-label visceral fat indication. Preferred over exogenous HGH for body composition goals.
Order from Peptide Pure →
Neuro / Cognitive
Cerebrolysin
IRBOut of Stock — On Order
★★★☆
Form
60mg/mL injectable (IV/IM)
Dose — General
5–30mL IV/IM daily × 10–20 days
Dose — Stroke
30mL IV daily × 21 days within 72h
Repeat
Every 3–6 months
Mechanism & Evidence
Porcine brain-derived neurotrophic peptide mixture (BDNF, NGF, CNTF). Promotes neuroplasticity and neuronal survival. Approved in 40+ countries for stroke recovery and cognitive decline. Multiple RCTs showing benefit in Alzheimer's and vascular dementia. Pairs with Semax for BDNF amplification and Methylene Blue for mitochondrial support.Alvarez et al., J Neural Transm (2011) · Allegri et al., Adv Ther (2011)
⚠ Contraindicated in epilepsy. Derived from porcine brain — confirm religious/dietary acceptability. Rare: agitation, insomnia, dizziness. Not FDA-approved in US.
Provider Notes
Our most potent neuro protocol compound. Essential in the Neuroregeneration Stack: post-TBI, stroke recovery, Parkinson's, Alzheimer's prevention. Add Semax (BDNF amplification), Selank (neuroinflammation control), BPC-157 (gut-brain axis), and HBOT.
Order from Peptide Pure →
Dihexa
IRBAdvanced
★☆☆☆
Form
Oral or SQ
Dose
10–20mg daily
Cycle
4–8 weeks on / 4 off
Escalation
Up to 40mg for neurodegeneration
Mechanism & Evidence
Angiotensin IV analog. 10 million times more potent than BDNF at forming new synapses in preclinical models (HGF/c-Met pathway). Drives synaptogenesis — literally builds new synaptic connections. Almost entirely preclinical data — use under strict IRB documentation and physician supervision.McCoy et al., J Pharmacol Exp Ther (2013)
⚠ HGF/c-Met cancer concern: contraindicated in patients with any cancer history. Monitor blood pressure. Primarily preclinical — limited human data. Full IRB informed consent required.
Provider Notes
Reserve for neurodegeneration, TBI recovery, Alzheimer's prevention. Pair with Semax for BDNF + synaptogenesis stack. Add Cerebrolysin post-TBI/stroke. Use conservatively — the preclinical data is extraordinary but human safety data is limited.
Order from Peptide Pure →
DSIP (Delta Sleep-Inducing Peptide)
IRBLow Stock · 9 — On Order
★★☆☆
Vial
10mg
Bac Water
2mL
Dose
100–200mcg SQ 30 min pre-bed
Duration
2–4 weeks
Reconstitution
10mg + 2mL = 5mg/mL · 100mcg = 2 units · 200mcg = 4 units
Mechanism & Evidence
Endogenous nonapeptide discovered 1977. Promotes delta-wave (deep) sleep without sedation. Normalizes HPA axis — modulates cortisol release in stress-disrupted patients. Restores natural sleep architecture rather than forcing sedation. No dependency, no grogginess, no withdrawal.Schneider-Helmert & Schoenenberger, Neuropsychobiology (1983) · Kovalzon, Neurosci Behav Physiol (2016)
Provider Notes
Best for cortisol-driven insomnia and disrupted circadian rhythm. Pairs with Epithalon for complete pineal restoration protocol. Distinct from melatonin and pharmaceutical sleep aids.
Order from Peptide Pure →
Methylene Blue
IRBAdvanced
★★★☆
IV Dose
0.5–2mg/kg over 30–60 min 1–2x/wk
Oral Dose
0.5–1mg/kg daily (USP grade only)
Sublingual/IN
Available
Cycle
4–8 weeks
Mechanism & Evidence
Electron carrier bypassing mitochondrial Complex I/III dysfunction. Enhances ATP production, reduces ROS, neuroprotective. MAOI antidepressant effects. Synergizes with PBM (same cytochrome c oxidase pathway). Pairs with NAD+ for comprehensive mitochondrial rescue.Rojas et al., Mol Neurobiol (2012) · Bhatt et al., Alzheimers Res Ther (2021)
⚠ CRITICAL: Serotonin syndrome with SSRIs/SNRIs/MAOIs — full medication reconciliation required before prescribing. Contraindicated in G6PD deficiency. Blue-green urine is expected and harmless.
Provider Notes
Part of the Brain Fog / Cognitive stack: pairs with Semax, Selank, Dihexa, NAD+. Excellent for post-COVID brain fog, cognitive aging, and mitochondrial dysfunction. Use USP pharmaceutical grade oral only — industrial grade is toxic.
Order from Peptide Pure →
Oxytocin
RxLow · 19
★★★☆
Intranasal Preferred
Vial
50mg
Route
Intranasal (preferred) · Sublingual
Dose IN
20–40 IU 1–2x daily
Timing
30 min before social interaction or therapy
Mechanism & Evidence
Bonding hormone delivered intranasally for CNS access. Modulates social cognition, reduces anxiety, anti-inflammatory, analgesic. Clinical trials: +50% eye contact and trust. Pairs with Selank for anxiety protocols. Essential in PTSD protocols — combines behavioral therapy with neurobiological support. No strict cycling required.Guastella et al., Biol Psychiatry (2010) · Feifel et al., Neuropsychopharmacology (2010)
Provider Notes
Intranasal route essential for CNS delivery. Use 30 minutes before therapy sessions or social exposure. Pairs with Selank (anxiety) and Semax (BDNF). Tolerance may develop with daily use — consider 5 on / 2 off cycling. Real human connection (group exercise, jiu-jitsu, contact sports) compounds effects permanently.
Order from Peptide Pure →
PE-22-28
IRBEmerging
★☆☆☆
Intranasal Preferred
Dose
100–500mcg SQ or IN daily
Route
Intranasal preferred for CNS delivery
Cycle
4–8 weeks · As-needed for acute mood
Evidence
Primarily preclinical
Mechanism & Evidence
TREK-1 potassium channel inhibitor. Rapid antidepressant effects comparable to ketamine in animal models — without dissociation. Promotes neurogenesis and BDNF expression. Very limited human data. Use under strict IRB documentation.Borsotto et al., Mol Psychiatry (2015)
⚠ Very limited human safety data. Use only under full informed consent and IRB documentation. Mild headache and injection site irritation reported. Monitor mood closely.
Provider Notes
Combine with Semax/Selank for full nootropic + mood stack. Pairs with Dihexa for synaptogenesis. Add to Cerebrolysin for neurodegeneration + depression. Intranasal preferred for fastest CNS onset.
Order from Peptide Pure →
Pinealon
IRBNEW SKU — On Order
★★☆☆
Vial
10mg
Bac Water
2mL
Dose
5–10mg SQ daily
Cycle
10 days on · 2–3x/year
Reconstitution
10mg + 2mL = 5mg/mL · 5mg = 100 units · 10mg = 200 units (use 50mg vial when available)
Mechanism & Evidence
Synthetic tripeptide (Glu-Asp-Arg) — Khavinson's pineal gland peptide. From the same gerontological research program that produced Epithalon. Specifically targets brain and pineal gland tissue. Promotes antioxidant defense in neural tissue, normalizes pineal melatonin synthesis, and has demonstrated neuroprotective and cognitive-enhancing effects in aging animal models. Significant mortality reduction in aging rodents.Khavinson et al., Bull Exp Biol Med (2002) · Khavinson & Morozov, Neuroendocrinol Lett (2003)
Provider Notes
NEW SKU — confirm supplier and pricing. Best combined with Epithalon as a complete Khavinson longevity protocol. 10-day courses 2–3x per year. Evening dosing. Particularly relevant for patients with cognitive decline, insomnia, and circadian dysfunction.
Order from Peptide Pure →
Selank
IRBIn Stock · 30
★★☆☆
Intranasal Preferred for Cognitive Effects
Vials
10mg · 30mg Amidate
Bac Water
2mL
Dose SQ
250–500mcg daily
Dose IN
200–400mcg 2–3x daily
Reconstitution + Routes
10mg + 2mL = 5mg/mL · 250mcg = 5 units · 500mcg = 10 units
Intranasal: preferred route for cognitive effects (faster CNS delivery via olfactory pathway)
SQ: for systemic anxiolytic and immune effects
Amidate version (30mg): enhanced stability, longer half-life — preferred
Mechanism & Evidence
Synthetic tuftsin analog — approved in Russia for generalized anxiety. Anxiolytic without sedation. Modulates GABA, serotonin, and dopamine. Enhances BDNF expression, improving memory consolidation. No addiction potential, no sedation, no withdrawal. The key differentiator from benzodiazepines.Meshavkin et al., Bull Exp Biol Med (2006) · Kozlovskii & Danchev, Neurosci Behav Physiol (2003)
Provider Notes
Intranasal for cognitive effects; SQ for systemic. Amidate version preferred — enhanced stability, longer half-life. Pair with Semax: Selank for calm, Semax for focus. Safe alongside SSRIs. Excellent for anxiety patients who want to avoid benzodiazepines.
Order from Peptide Pure →
Semax
IRBCritical Low · 4 — On Order
★★★☆
Intranasal Only for Peak CNS Effects
Vial
10mg
Bac Water
2mL
Dose IN
200–600mcg 2–3x daily
Cycle
10–14 days on / 10 days off
Reconstitution + Delivery
10mg + 2mL = 5mg/mL · 200mcg = 4 units · 400mcg = 8 units · 600mcg = 12 units
Intranasal ONLY for optimal CNS effects — olfactory nerve delivers directly to brain
SQ works systemically but doesn't cross BBB as effectively
Acute neuro conditions: up to 1,200mcg/day IN
Mechanism & Evidence
Synthetic ACTH analog. Approved in Russia and Ukraine for stroke recovery. Potent BDNF upregulator — increases brain-derived neurotrophic factor more than any other known peptide. Neuroprotective in ischemic stroke models. Enhances attention, memory, and learning without stimulant effects.Ashmarin et al., Curr Med Chem (2005) · Dolotov et al., Brain Res (2006) · Levitskaya et al., Neurosci Behav Physiol (2008)
Provider Notes
Our top nootropic peptide. Short cycles with equal rest period. Pairs with Selank for complete neuro stack. TBI recovery, post-COVID brain fog, cognitive aging — consistently positive outcomes. Critical stock level — on order.
Order from Peptide Pure →
Immune Modulation
KPV
IRBDual Route · In Stock · 30
★★☆☆
Vial
10mg
Routes
SQ · Oral · Intranasal
Dose SQ
200–500mcg daily
Dose Oral
500mcg–1mg BID (survives gastric acid)
Reconstitution + Routes
10mg + 2mL = 5mg/mL · 200mcg = 4 units · 500mcg = 10 units
Oral: dissolve in water or capsule — tripeptide size survives stomach acid
Intranasal: for neuroinflammation applications
Mechanism & Evidence
C-terminal tripeptide of alpha-MSH. Inhibits NF-κB directly in cell nucleus. Reduces intestinal inflammation in colitis models by 50–70%. Unique triple-route capability is the key differentiator. Context-dependent: active in inflamed tissue, inert in healthy tissue.Kannengiesser et al., J Pharmacol Exp Ther (2007) · Brzoska et al., Endocr Rev (2008)
Provider Notes
Oral for IBD, colitis, SIBO, leaky gut. SQ for systemic autoimmune inflammation, psoriasis, eczema. Heavy use in our autoimmune population alongside Thymosin Alpha-1. Also available in Peptide Buzz Total Body Repair powder.
Order Injectable →OTC Oral via Peptide Buzz →
LL-37 (Cathelicidin)
IRBAdvanced
★★☆☆
Dose SQ
50–100mcg daily near infection site
Route Nasal
Nebulized for respiratory biofilm
Route Sinus
Intranasal for sinus biofilm
Duration
4–8 weeks
Mechanism & Evidence
Human cathelicidin — broad-spectrum antimicrobial. Active against bacteria, fungi, viruses, and biofilms. Modulates innate immunity and promotes wound healing. Essential in Lyme/biofilm protocols. Pairs with KPV for antimicrobial + anti-inflammatory combination.Zanetti, J Leukoc Biol (2004) · Wang et al., Amino Acids (2014)
⚠ Herxheimer reactions expected as biofilms break — warn patients of temporary symptom flare. Caution in autoimmune conditions (amplifies innate immunity). Injection site pain common.
Provider Notes
Essential in chronic Lyme, mold/CIRS, and persistent biofilm protocols. Combine with IV Vitamin C for acute infection. Add ozone (alternate days). Pair with BPC-157 for infected tissue repair.
Order from Peptide Pure →
Thymosin Alpha-1
Approved 35+ CountriesLow Stock · On Order
★★★☆
Vial
10mg
Bac Water
2mL
Dose
1.6mg SQ daily or every other day
Duration
Acute: daily ×4wks · Maintenance: 2–3x/wk
Reconstitution
10mg + 2mL = 5mg/mL · 1.6mg = 32 units
1.6mg is the FDA-approved Zadaxin dose in jurisdictions where approved. 2x/week is the standard ONZEN maintenance protocol.
Mechanism & Evidence
28-amino-acid thymic peptide. Approved as Zadaxin in 35+ countries for hepatitis B/C and immune adjuvant. Matures dendritic cells, activates NK cells, restores Th1/Th2 balance. One of the most clinically studied peptides globally. Decades of human data in oncology, chronic infection, and post-COVID immune restoration.Tuthill et al., Ann N Y Acad Sci (2010) · Romani et al., Curr Opin Pharmacol (2016)
Provider Notes
Immune modulation, not immunostimulation — safe in autoimmune patients at standard doses. Excellent for: chronic viral infections, post-COVID fatigue/dysregulation, pre-surgical immune optimization, cancer adjuvant support. The 35-country regulatory approval is among the strongest compliance arguments for any peptide in our formulary.
Order from Peptide Pure →
Thymulin
IRBAdvanced
★★☆☆
Dose
150–250mcg SQ/IM daily
Duration
6–8 weeks standard · 3–10 days high-dose
Required
Zinc 30mg/day — essential for activity
Cycle
Quarterly maintenance after initial course
Mechanism & Evidence
Zinc-dependent thymic nonapeptide. Drives T-cell maturation and thymic regeneration. Reverses immunosenescence. Has a unique ACTH neuroendocrine bridge — connects immune and endocrine systems. Pairs with Thymosin Alpha-1 for comprehensive dual thymic protocol.Dardenne et al., Proc Natl Acad Sci (1982) · Bach, Prog Clin Biol Res (1983)
⚠ Zinc is REQUIRED for activity — always co-administer zinc 30mg/day + Vitamin D3. Caution in severe immunosuppression and autoimmune disease. Transient restlessness/agitation possible.
Provider Notes
Pairs with TA-1 for dual thymic protocol — the most comprehensive immune rejuvenation stack in our formulary. Essential in Immune Reset Stack. Add KPV for inflammatory control.
Order from Peptide Pure →
VIP (Vasoactive Intestinal Peptide)
RxAdvanced / CIRS
★★☆☆
Intranasal Only
Route
Intranasal — 50mcg/spray
Dose
4 sprays (200mcg) 4x daily
Duration
30-day initial course
Prerequisite
MARCoNS must be cleared first
Mechanism & Evidence
28-amino-acid neuropeptide — capstone of Shoemaker CIRS protocol. Regulates innate immunity, reduces TGF-β and MMP-9, restores regulatory T-cells. Used specifically in Chronic Inflammatory Response Syndrome (CIRS) from mold exposure, Lyme, and biotoxin illness after other steps are complete.Shoemaker & House, Neurotoxicol Teratol (2006) · Sompayrac, How the Immune System Works (2019)
⚠ MUST NOT start until MARCoNS nasal staph is cleared (VIP feeds biofilm if MARCoNS present). Must pass VCS visual contrast sensitivity screening first. Monitor VEGF, TGF-β, C4a during treatment. Diarrhea dose-dependent.
Provider Notes
Used within the full Shoemaker CIRS protocol as a late-step intervention. Combine with KPV for anti-inflammatory coverage. Add Glutathione for detox support. Do not prescribe without full CIRS workup.
Order from Peptide Pure →
Longevity & Anti-Aging
Epithalon
IRBIn Stock · 10mg: 30 · 50mg: 61
★★☆☆
Vials
10mg · 50mg
Bac Water
2mL
Dose
5–10mg SQ daily (evening)
Cycle
10–20 days · 2–3x/year
Reconstitution
10mg + 2mL = 5mg/mL · 5mg = 100 units (full syringe)
For 10mg/day: use the 50mg vial. Short courses — not chronic daily use.
Mechanism & Evidence
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) — Dr. Vladimir Khavinson's 40-year life's work. Activates telomerase, extends telomere length in human somatic cells. Landmark 6-year study: 46% mortality reduction in elderly patients. Regulates pineal melatonin, restoring circadian rhythm in aging. The most studied longevity peptide in existence.Khavinson et al., Bull Exp Biol Med (2003) · Anisimov et al., Biogerontology (2003)
⚠ Absolute contraindication: active cancer (telomerase activation could promote malignant cell growth).
Provider Notes
Short cycles: 10–20 days, 2–3x per year. Evening dosing (pineal support). Pairs with Thymosin Alpha-1 for immune + longevity. Monitor telomere length annually (TruDiagnostic). Russian research is legitimate peer-reviewed science — indexed differently than US journals.
Order from Peptide Pure →
Glutathione
IRB600mg: 30 · 1500mg: On Order
★★★☆
Vials
600mg · 1,500mg
Recon (600mg)
6mL sterile water = 100mg/mL
Dose SQ/IM
200–400mg 2–3x/wk
IV Push
600–2,000mg over 5–10 min
Reconstitution
600mg + 6mL = 100mg/mL · 200mg = 20 units · 400mg = 40 units
IV push: dilute in 10–20mL saline, push slowly — cramping if rushed
Mechanism & Evidence
The master antioxidant. Most abundant intracellular antioxidant. Regenerates vitamins C and E, supports Phase II liver detoxification, maintains mitochondrial function. Parenteral achieves plasma levels unattainable orally. Critical for mold/toxin exposure, Parkinson's, post-chemo recovery.Sekhar et al., Am J Clin Nutr (2011) · Gaucher et al., Antioxidants (2018)
Provider Notes
Foundational to any detox or anti-aging protocol. Pairs synergistically with NAD+. IV push at clinic for acute loading; SQ/IM for home maintenance. Avoid within 30 minutes of ozone therapy (negates oxidative signal). Skin lightening is common patient-reported side effect.
Order from Peptide Pure →
MOTS-c
IRBOut of Stock — On Order
★★☆☆
Vial
10mg
Bac Water
2mL
Dose
5–10mg SQ 3–5x/week
Timing
Time with exercise for synergy
Reconstitution
10mg + 2mL = 5mg/mL · 5mg = 100 units · 10mg = 200 units (use 10mg vial)
Mechanism & Evidence
Mitochondria-derived peptide — the exercise mimetic. Activates AMPK, mimicking metabolic benefits of physical activity. Improves insulin sensitivity, reduces adiposity, demonstrates anti-aging effects. Declines with age. Increases with exercise — supplementation extends the metabolic benefit window.Lee et al., Cell Metab (2015) · Reynolds et al., Nature Aging (2021)
Provider Notes
Excellent for metabolically compromised patients who can't exercise — post-surgical, obese, elderly. Pairs with NAD+ for full mitochondrial support. On order — critical shortfall per current inventory.
Order from Peptide Pure →
NAD+
IRBIn Stock · 164
★★★☆
Vial
1,000mg
Recon
5mL sterile water
Dose IM
25 units (50mg) 2x/week
Route
IM ONLY — deltoid or glute
Reconstitution — Our 5mL Standard
1,000mg + 5mL sterile water = 200mg/mL
25 units = 50mg per injection · 100mg/week total
Our 5mL reconstitution gives cleaner math than the standard 10mL (25u vs 50u)
⚠ IM injection ONLY — SQ burns significantly. Deltoid or glute. ALWAYS confirm vial reads 1,000mg before adding 5mL. Contraindicated in active malignancy.
Mechanism & Evidence
Nicotinamide adenine dinucleotide — the master regulator of cellular energy. Declines ~50% between ages 40–60. Essential for sirtuins (SIRT1–7), PARP DNA repair, and mitochondrial complex I. IV/IM achieves cellular levels unattainable orally. Foundation of every longevity protocol we run.Rajman et al., Cell Metab (2018) · Martens et al., Nature Aging (2023)
Provider Notes
Foundation longevity compound — combine with Epithalon, MOTS-c, GHK-Cu for comprehensive stack. Pairs with Glutathione post-infusion. Add on HBOT days. Trending biomarkers: monitor CRP, homocysteine, methylation markers alongside IGF-1. Patients report energy, clarity, and improved sleep within 1–2 weeks.
Order from Peptide Pure →
Rapamycin
FDA-Approved (Transplant)Rx · Off-label
★★★☆
Form
Oral tablet
Dose
3–6mg once weekly (intermittent)
Schedule
8 weeks on / 2 off · Some use 5mg every 5 days
Key
Intermittent dosing is critical — not daily
Mechanism & Evidence
mTOR inhibitor. Low intermittent doses enhance immunity (paradox: immunosuppressant at transplant doses, immune-enhancing at longevity doses), clear senescent cells, activate autophagy. Extends lifespan in every organism tested — the most robust longevity intervention in animal models. First drug to extend median lifespan in adult mice.Harrison et al., Nature (2009) · Mannick et al., Sci Transl Med (2014)
⚠ Mouth ulcers = dose too high. Monitor lipids, CBC, fasting glucose regularly. Not during active infection. Avoid combining with strong CYP3A4 inhibitors (some azole antifungals, grapefruit). Immunosuppression at daily/high doses — intermittent weekly protocol is key.
Provider Notes
The most evidence-supported longevity intervention that currently exists. Pair with Epithalon (telomere + autophagy), NAD+ IV, and MOTS-c for metabolic synergy. Intermittent weekly dosing is the entire key — not daily. Prescription required (off-label).
Order from Peptide Pure →
Senolytics (Dasatinib + Quercetin)
Rx + OTCAdvanced
★★☆☆
Dasatinib
100mg oral daily × 3 days
Quercetin
1,000mg oral daily × 3 days
Schedule
3 consecutive days monthly or quarterly
Alternative
Fisetin 20mg/kg × 2 days can replace Quercetin
Mechanism & Evidence
"Hit and run" senolysis. Dasatinib + Quercetin selectively eliminate senescent "zombie cells" that accumulate with age, secreting SASP (senescence-associated secretory phenotype) — a cocktail of pro-inflammatory cytokines driving every chronic disease. Mayo Clinic Phase 1/2 data shows improved physical function in idiopathic pulmonary fibrosis and diabetic kidney disease.Xu et al., EBioMedicine (2018) · Justice et al., EBioMedicine (2019)
⚠ Dasatinib: edema, cytopenias, pleural effusion at standard cancer doses (rare at senolytic doses). Requires physician monitoring. GI upset during dosing days expected.
Provider Notes
Combine with Rapamycin for autophagy + senolysis together. Add Epithalon post-clearance for telomere support. NAD+ IV supports cellular renewal after senolytic pulse. The 3-day intermittent protocol minimizes risk while capturing benefit.
Order from Peptide Pure →
SS-31 (Elamipretide)
IRBOut of Stock — On Order
★★★☆
Vial
10mg
Bac Water
2mL
Dose
5–20mg SQ daily
Cycle
8–12 weeks
Reconstitution
10mg + 2mL = 5mg/mL · 5mg = 100 units · 10mg = 200 units (use 50mg vial)
FDA Breakthrough Designation dose (Barth syndrome): 40mg/day
Mechanism & Evidence
Mitochondria-targeted tetrapeptide — binds cardiolipin in inner mitochondrial membrane. Stabilizes electron transport chain, rescues failing mitochondria. Phase 2 SPARCL trial: improved exercise tolerance and cardiac function in HFpEF. FDA Breakthrough Designation for Barth syndrome.Szeto, Pharm Res (2011) · Daubert et al., JACC Heart Fail (2017)
Provider Notes
Go-to for cardiac patients, high-oxidative-stress conditions, CKD, and mitochondrial dysfunction. Pairs with NAD+ + MOTS-c for complete mitochondrial support triple-stack. Add Methylene Blue for fourth-pathway support.
Order from Peptide Pure →
Sexual Health
PT-141 (Bremelanotide)
FDA-Approved (Vyleesi)In Stock · 44
★★★★
Intranasal Option Available
Vial
10mg
Bac Water
2mL
Dose SQ
10–20 units PRN · 45–60 min before
Duration
Effect lasts 24–72 hours from single dose
Reconstitution + Routes
10mg + 2mL = 5mg/mL · 10u = 0.5mg · 15u = 0.75mg · 20u = 1mg
Intranasal: faster onset, lower systemic nausea — use nasal atomizer · ~0.5mg per nostril
SQ: abdominal · Start LOW — 10 units. Most respond better than expected at lower doses.
Mechanism & Evidence
FDA-approved MC4 receptor agonist (Vyleesi). CNS mechanism — activates hypothalamic MC4R to produce genuine arousal, not just blood flow. Only FDA-approved on-demand treatment for HSDD in premenopausal women. Effective in men and women. Do NOT combine with Melanotan-2 (shared melanocortin pathway — additive side effects).Kingsberg et al., Obstet Gynecol (2019) · Clayton et al., JAMA (2016)
Provider Notes
Start at 10–15 units. Less is more — most patients over-dose initially. Nausea is dose-dependent and eliminates at lower doses. Works equally for men and women. BP elevation transient — caution with uncontrolled hypertension. Pair with Oxytocin nasal for enhanced bonding component.
Order from Peptide Pure →
Tadalafil (Low-Dose Daily)
FDA-ApprovedRx
★★★★
Dose (Daily)
2.5–5mg oral daily
Dose (PRN)
10–20mg as needed · 30–60 min before
Half-Life
17.5 hours — the longest PDE5i
FDA Indications
ED · BPH · Pulmonary arterial hypertension
Mechanism & Evidence
PDE5 inhibitor — FDA-approved (Cialis). Inhibits phosphodiesterase-5, increasing cGMP, relaxing smooth muscle, and increasing blood flow. Daily low-dose (2.5–5mg) maintains continuous cardiovascular and penile endothelial health — beyond the episodic PRN use. Emerging cardiovascular protection data at low doses. Also used off-label for Raynaud's, altitude sickness, and endothelial dysfunction.Porst et al., Eur Urol (2006) · Vlachopoulos et al., J Am Coll Cardiol (2013)
⚠ Absolute contraindication: nitrates (any form). Caution with alpha-blockers (hypotension). BP monitoring in patients on antihypertensives. Do not combine with PT-141 without BP monitoring.
Provider Notes
Daily 5mg is superior to PRN dosing for overall endothelial health and patient satisfaction. Particularly valuable in TRT protocols — exogenous testosterone + daily tadalafil is the modern sexual health optimization protocol. Emerging use in metabolic syndrome for endothelial benefit.
Order from Peptide Pure →
Cosmetic & Skin
Botulinum Toxin (Botox)
FDA-ApprovedRxIn Stock · 30
★★★★
Vial
100 units
Reconstitution
2.5mL saline = 4 units/0.1mL
Dose
20–80 units per session (cosmetic)
Duration
3–4 months
Mechanism & Evidence
Clostridium botulinum neurotoxin type A. Blocks acetylcholine release at neuromuscular junction, temporarily paralyzing targeted muscles. FDA-approved for multiple cosmetic and therapeutic indications. Beyond cosmetic: treatment for hyperhidrosis, migraine, TMJ, spasticity, and overactive bladder.
Provider Notes
Standard cosmetic areas: glabella (11s), forehead, crow's feet. Therapeutic: masseter (TMJ), platysma, trapezius (headache), underarms (hyperhidrosis). Pairs with GHK-Cu topical and PRP facials for comprehensive cosmetic protocol. Onset 3–5 days, full effect at 2 weeks.
Order from Peptide Pure →
GHK-Cu (Copper Peptide)
IRBIn Stock · 50mg: 35 · 100mg: 31
★★☆☆
Vials
50mg · 100mg
Bac Water
2mL
Dose SQ
1–2mg daily
Topical
1–2% cream daily (Peptide Buzz)
Reconstitution
50mg + 2mL = 25mg/mL · 1mg = 4 units · 2mg = 8 units
Co-supplement zinc 30mg/day. Avoid concurrent copper supplements.
Mechanism & Evidence
Naturally occurring tripeptide-copper complex — modulates 30%+ of human genes. Activates collagen I, III, V synthesis, decorin, and glycosaminoglycans. 100+ published studies. Promotes wound healing, hair growth, systemic anti-inflammatory. Both injectable and topical applications. Declines with age.Pickart et al., Oxidative Med Cell Longev (2012) · Pickart et al., Biomedicines (2018)
Provider Notes
Dual use — injectable for systemic anti-aging, topical for skin/hair. Featured in Peptide Buzz Tallow Balm and SNAP-8 Serum. 100mg vials for higher-volume providers. Contraindicated in Wilson's disease — monitor copper/zinc ratio with long-term use.
Order Injectable →OTC Topical via Peptide Buzz →
Melanotan-2 (MT-2)
IRBIn Stock · 68
★★☆☆
Vial
10mg
Bac Water
2mL
Dose
250–500mcg SQ daily (loading)
Maintenance
250mcg 1–2x/week
Reconstitution
10mg + 2mL = 5mg/mL · 250mcg = 5 units · 500mcg = 10 units
Loading: 250mcg daily × 2–3 weeks with minimal sun. Maintenance: 250mcg weekly.
Mechanism & Evidence
Synthetic melanocortin receptor agonist. Stimulates melanogenesis — natural tan without UV. Originally developed at University of Arizona for skin cancer prevention. Also activates MC4R (arousal) and MC3R (appetite suppression). Do NOT combine with PT-141 (shared pathway — additive side effects).Dorr et al., Ann N Y Acad Sci (2003) · Hadley & Dorr, Peptides (2006)
⚠ Monitor moles — any new or changing moles require dermatology referral. Contraindicated in personal or family history of melanoma. Sexual arousal and spontaneous erections are expected MC4R side effects — counsel patients before prescribing.
Provider Notes
Start at 250mcg — nausea is common at first dose and resolves. Pairs with GHK-Cu for complete skin quality + pigmentation protocol. Do not stack with PT-141.
Order from Peptide Pure →
SNAP-8
TopicalLow · 20
★★☆☆
Form
Topical / serum base
Concentration
4–10% in formulation
Application
2x daily to expression lines
Onset
4–8 weeks continuous use
Mechanism & Evidence
Octapeptide analog of SNAP-25 — a protein in the SNARE complex. Inhibits the neurotransmitter release mechanism at the neuromuscular junction topically. Marketed as a topical alternative to neuromodulators. Reduces muscle contraction depth at expression lines (forehead, glabella, crow's feet). Synergistic with GHK-Cu in our Royale Repair serum line.Blanes-Mira et al., Int J Cosmet Sci (2002)
Provider Notes
Featured in Peptide Buzz SNAP-8 Serum. Best for patients who want cosmetic improvement without injectables. Pair with GHK-Cu 2% cream for full dermal remodeling protocol. Available for compounding into custom serum bases.
Order from Peptide Pure →Via Peptide Buzz →
IV & Infusion
IV Vitamin C (High-Dose)
IRBClinical Protocol
★★★☆
Dose (Immune)
25g 1–2x weekly
Dose (Oncology)
50–100g 2–3x weekly
Dose (Acute)
25–50g daily × 3–5 days
Infusion Time
1–3 hours (rate-dependent)
Mechanism & Evidence
At pharmacologic IV doses: pro-oxidant generating selective H₂O₂ targeting cancer cells and pathogens. At lower doses: immune support and collagen synthesis. 100% bioavailability vs. oral's 15–20% ceiling. Follow with Glutathione push. Do NOT combine with ozone same day (negates oxidative signal).Padayatty et al., Ann Intern Med (2004) · Mikirova et al., J Transl Med (2012)
⚠ MUST screen G6PD deficiency before first infusion (hemolysis risk). Falsely elevates glucometer readings during infusion. Kidney stones in susceptible patients. Avoid in iron overload. Coordinate with oncologist before combining with chemotherapy.
Provider Notes
Foundation of acute infection protocols. Follow with Glutathione push. Combine with Myers' Cocktail as base. Pair with LL-37 for biofilm + antimicrobial combination.
Order from Peptide Pure →
Lipo-C+
IRBOut of Stock — On Order
Form
10mL multi-dose vial
Dose
1mL IM 2–3x/week
Contents
MIC (Methionine, Inositol, Choline) + B12 + L-Carnitine
Duration
8–12 weeks
Mechanism & Evidence
Lipotropic injection combining MIC + B12 + L-Carnitine. Methionine: essential amino acid for fat metabolism. Inositol: insulin signal transduction, fat redistribution. Choline: hepatic fat transport, prevents fatty liver. B12: energy metabolism. L-Carnitine: mitochondrial fatty acid oxidation. Widely used in weight loss clinics as adjunct to GLP-1 protocols.
Provider Notes
Excellent adjunct to GLP-1 protocols — supports hepatic fat metabolism during rapid weight loss. Pairs with Retatrutide or Tirzepatide for comprehensive metabolic protocol. IM only — gluteal or deltoid. Currently out of stock, on order.
Order from Peptide Pure →
Myers' Cocktail
IRBStandard IV Foundation
★★★☆
Magnesium
2g
Calcium
1g
B-Complex + B12
1mg B12 + B-complex
Vitamin C
5–10g (or add high-dose separately)
Mechanism & Evidence
The original IV nutrient infusion. 100% bioavailability bypassing GI absorption ceiling. Foundation of modern IV therapy — primes cellular machinery for all subsequent IV protocols. Infuse over 30–45 minutes. Customizable based on patient needs.Gaby, Altern Med Rev (2002)
Provider Notes
Base layer for all IV protocols. Add Glutathione push at end. Layer IV Vitamin C for immune indication. Precedes NAD+ (primes cellular energy machinery). Infuse slowly — Mg causes vasodilation/warmth if pushed fast. Very safe; rare hypotension in hypovolemic patients.
Order from Peptide Pure →
Regenerative Medicine & Procedures
A2M (Alpha-2-Macroglobulin)
IRBClinic Procedure
★★☆☆
Source
Autologous blood draw
Process
Centrifuge → concentrate → inject
Application
Intra-articular
Repeat
Every 6–12 months
Mechanism & Evidence
Autologous protease inhibitor. Neutralizes destructive MMPs (matrix metalloproteinases) in degenerative joints — literally stops cartilage breakdown at the enzymatic level. Excellent combination with PRP: A2M protects, PRP rebuilds. Can precede stem cell therapy.Shetty et al., Curr Rev Musculoskelet Med (2018)
Provider Notes
Pair with PRP for the protect + rebuild combination. BPC-157 SQ near the joint accelerates response. HBOT post-procedure improves oxygenation during repair. Requires specialized centrifuge. Limited availability outside larger regenerative medicine centers.
Order from Peptide Pure →
Exosomes
IRB · 21 CFR 1271Clinical Protocol
★★☆☆
IV Dose
10–30 billion per session
Intra-articular
2–5 billion per joint
Topical
With microneedling post-PRP
Sessions
1–3 sessions · 4–8 weeks apart
Mechanism & Evidence
Cell-derived extracellular vesicles carrying mRNA, miRNA, and growth factors. Biological FedEx — regenerative instructions without live cell risks. Layer onto PRP for synergistic joint and aesthetic protocols. Combine with HBOT post-infusion. All biologics from FDA-registered tissue banks per 21 CFR Part 1271.Théry et al., Nature Rev Immunol (2009) · Caplan & Dennis, J Cell Biochem (2006)
⚠ Quality control is the #1 issue — use only FDA-registered tissue bank sources with full documentation. Inflammatory flare 24–48 hours post-infusion expected. Avoid combining with IV Vitamin C same day. Contraindicated in active infection.
Provider Notes
Clinical regenerative services at mortensenmedical.com. Pair with PRP, BPC-157/TB-500 peri-procedure, and HBOT for maximum regenerative response.
Order from Peptide Pure →
PRP (Platelet-Rich Plasma)
IRBClinic Procedure
★★★★
Process
Blood draw → centrifuge → inject
Joints
3–6mL · Series of 3 · 4–6 weeks apart
Hair
Monthly × 3 · Maintenance quarterly
Facial
Microneedling + PRP monthly × 3
Mechanism & Evidence
Autologous platelet concentrate (3–7× concentration) delivering 1,500+ growth factors. Workhorse of regenerative orthopedics and aesthetics. Multiple RCTs for knee OA, rotator cuff, and hair loss. Avoid NSAIDs 1 week pre/post (blunts platelet activation).Mishra et al., PM&R (2014) · Moraes et al., Br J Sports Med (2014)
Provider Notes
Combine with A2M for joint protection + rebuild. Layer with Exosomes for enhanced signal. BPC-157 SQ near joint accelerates response. HBOT post-PRP. Results take 4–12 weeks — set patient expectations. Quality varies by prep method — 3-spin minimum, leukocyte concentration matters by indication.
Order from Peptide Pure →
Stem Cells (MSCs)
IRB · 21 CFR 1271Clinical · mortensenmedical.com
★★★☆
IV Systemic
50–200 million cells
Intra-articular
5–20 million per joint
Sessions
1–3 · 3–6 months apart
Source
FDA-registered tissue bank · COA required
Mechanism & Evidence
Mesenchymal stem/stromal cells from bone marrow, adipose, or umbilical cord. Home to inflammation/injury, secreting anti-inflammatory cytokines, growth factors, and exosomes. Multiple human trials for osteoarthritis, MS, and cardiac repair. All sourced from FDA-registered tissue banks per 21 CFR Part 1271.Caplan, Cell Stem Cell (2017) · Squillaro et al., Cell Transplant (2016)
⚠ Demand cell count, viability (>80%), and sterility documentation from every source. Avoid in active malignancy. Fever and headache post-infusion are expected and transient (24–48 hrs). HBOT pre-treatment mobilizes endogenous stem cells and primes the environment.
Provider Notes
Clinical regenerative services at mortensenmedical.com. Pretreat with HBOT. Peri-procedure BPC-157/TB-500 SQ. Follow with Exosomes. NAD+ IV supports transplanted cell energy metabolism.
Order from Peptide Pure →
Proprietary Blends
GLOW
IRBIn Stock · 97
Vial
70mg blend
Bac Water
3mL
Dose
Per blend protocol — see chart
Route
SQ · Topical per formulation
Reconstitution — 3mL Standard
70mg blend + 3mL = 23.3mg/mL
Confirm component breakdown with dispensing provider before reconstituting.
Proprietary Cosmetic + Longevity Blend
GLOW is a curated peptide blend designed for cosmetic and dermal anti-aging applications. Component peptides target collagen synthesis, skin remodeling, and systemic anti-aging pathways. Contact your ONZEN clinical rep for full formula disclosure under provider agreement.
Provider Notes
Best combined with GHK-Cu topical, PRP facial protocols, and CJC/Ipamorelin for inside-out cosmetic outcomes. Well stocked — 97 units. Prescribe with full IRB documentation.
Order from Peptide Pure →
KLOW
IRBOut of Stock — 8 Kits on Order
Vial
80mg blend
Bac Water
3mL
Dose
Per blend protocol — see chart
Route
SQ
Reconstitution — 3mL Standard
80mg blend + 3mL = 26.7mg/mL
Confirm component breakdown with dispensing provider before reconstituting.
Proprietary Metabolic / Weight Loss Blend
KLOW is a curated blend designed for metabolic optimization and weight management. Combines lipotropic and metabolic peptide components for synergistic fat reduction beyond standalone GLP-1 protocols. Full formula disclosure under provider agreement.
Provider Notes
Currently out of stock — 8 kits on order. Expected restock imminent. Best layered with GLP-1 protocols (Retatrutide or Tirzepatide) for enhanced metabolic outcomes. Contact your ONZEN rep for restock timeline.
Order from Peptide Pure →
Super Human Blend
IRBLow · 18
Vial
10mL multi-dose
Route
SQ / IM per component
Dose
Per blend protocol
Status
Low stock — reorder approaching
Proprietary Multi-Peptide Performance Blend
Super Human Blend is a curated multi-peptide formulation targeting recovery, performance, and longevity through complementary peptide pathways. Designed to replace multiple individual vials with a single convenient administration protocol. Full formula disclosure under provider agreement with ONZEN.
Provider Notes
18 units remaining — approaching reorder threshold. Order to maintain continuity for existing patients already on this protocol. Contact ONZEN clinical team for full component disclosure and prescribing guide.
Order from Peptide Pure →
Devices & Procedures
HBOT (Hyperbaric Oxygen Therapy)
FDA-Approved · 14 IndicationsClinical Service
★★★★
Pressure
1.5–2.4 ATA pressurized 100% O₂
Standard Protocol
40 sessions · 60–90 min · 5x/week × 8 weeks
Mild Protocol
1.3–1.5 ATA · 2–3x/week
TBI Acute
Within 72 hours + Cerebrolysin
Mechanism & Evidence
Supraphysiologic tissue oxygenation at 10–15× normal atmospheric pressure. Mobilizes stem cells from bone marrow, drives angiogenesis, and activates regenerative gene expression. FDA-approved for 14 conditions including wound healing, carbon monoxide poisoning, osteonecrosis, and decompression sickness. Off-label: TBI, stroke recovery, long COVID, autism, neurodegeneration.Efrati et al., PLOS ONE (2013) · Harch et al., J Neurotrauma (2012)
⚠ Ear/sinus barotrauma is the most common side effect — equalize pressure. Temporary myopia with extended courses. Rare: O₂ toxicity seizure at very high pressures. Absolute contraindication: untreated pneumothorax.
Provider Notes
Synergistic with stem cells and exosomes — pretreat with HBOT to mobilize endogenous stem cells before procedures. Pairs with NAD+ IV, BPC-157/TB-500, and Cerebrolysin for TBI/stroke protocols. PBM pre-session enhances photobiomodulation. Schedule HBOT days to coincide with NAD+ IV for maximum mitochondrial loading.
Order from Peptide Pure →
Ozone Therapy (MAH / 10-Pass)
IRBClinical Procedure
★★☆☆
MAH
1 pass · 1–3x/week
10-Pass
10 cycles/session · Weekly × 10
Rectal
Home maintenance daily
Nebulized
Respiratory biofilm protocols
Mechanism & Evidence
Medical O₃ creates controlled oxidative stress activating Nrf2 — the master antioxidant pathway. Improves O₂ delivery, broad antimicrobial effects at therapeutic doses. Major Autohemotherapy (MAH): blood drawn, ozonated, reinfused. 10-Pass is high-dose protocol for chronic conditions. Used in Lyme, CIRS, chronic fatigue, and oncology adjuvant protocols.Elvis & Ekta, J Nat Sci Biol Med (2011) · Sagai & Bocci, Med Gas Res (2011)
⚠ Do NOT combine with IV Vitamin C same day — ozone creates oxidative signal, glutathione/vitamin C negates it. Contraindicated: G6PD deficiency, active hyperthyroidism, pregnancy. Not FDA-approved. Herxheimer reactions expected in biofilm protocols.
Provider Notes
Alternate days with IV Vitamin C (never same day). Combine with LL-37 for biofilm disruption. Follow with Glutathione (wait 30 min minimum). Add to HBOT for synergistic oxygen optimization. CIRS protocol staple alongside VIP and KPV.
Order from Peptide Pure →
PBM (Photobiomodulation / Red Light)
FDA-ClearedIn-Clinic + Home
★★★☆
Wavelengths
Red 630–670nm · NIR 810–850nm
General
10–20 min daily · 6–12" distance
Transcranial
810nm · 10–12 min daily
Targeted
2–10 min per area · 2x daily acute
Mechanism & Evidence
Activates cytochrome c oxidase (Complex IV of mitochondrial ETC), boosting ATP production 50%+. Red light (630–670nm) penetrates superficial tissue — skin, joints, wound healing, collagen synthesis. NIR (810–850nm) penetrates deeper — muscle, bone, and transcranially for neurological applications. Synergistic with Methylene Blue (same cytochrome pathway). GHK-Cu topical potentiates skin PBM effects.Hamblin, Photobiomodul Photomed Laser Surg (2018) · Chung et al., Ann Biomed Eng (2012)
Provider Notes
Biphasic response — more is NOT better. Optimal dose is specific; overdosing reverses the effect. Eye protection required for all treatments. Use pre-PEMF or pre-cryo for sequenced protocols. Transcranial 810nm pairs with Semax/Selank in Neuroregeneration Stack. 630nm facial pairs with GHK-Cu topical in Cosmetic Stack. Avoid over thyroid gland.
Order from Peptide Pure →
PEMF (Pulsed Electromagnetic Field)
FDA-ClearedIn-Clinic + Home
★★★☆
Whole Body
8–30 min · 1–2x daily · Mat device
Localized
15–30 min on target · 1–100 Hz
Cycling
No cycling required — daily use OK
rTMS
FDA-approved for treatment-resistant depression
Mechanism & Evidence
Low-frequency electromagnetic pulses stimulate cellular repair, ATP production, microcirculation, and reduce inflammation. Accelerates bone healing — the original FDA-cleared indication. Activates voltage-gated calcium channels, increasing intracellular Ca²⁺ which drives healing cascades. rTMS is a high-frequency variant FDA-approved for depression and OCD.Hannemann et al., J Orthop Res (2020) · O'Reardon et al., Biol Psychiatry (2007)
⚠ Avoid with implanted pacemakers, cochlear implants, insulin pumps, and implanted metal. Avoid over tumors. Safe for most patients otherwise.
Provider Notes
Sequence: PEMF → PBM for layered cellular stimulation. Combines with BPC-157/TB-500 in Injury Recovery Stack — devices amplify peptide repair signals. Pair with WBV for bone density protocols. Use post-HBOT for maximum effect. Home mat devices available for daily maintenance between clinic visits.
Order from Peptide Pure →
Cryotherapy (WBC)
Clinical Service
★★★☆
Temperature
-110°C to -160°C · 2–3 minutes
Acute
3–5x/week
Maintenance
1–2x/week · Always supervised
Home Alternative
Cold shower / ice bath · 5–15 min
Mechanism & Evidence
Extreme cold triggers anti-inflammatory cascade, massive norepinephrine surge (+300–500%), and cold-shock protein activation. Norepinephrine drives focus and mood for 3–5 hours post-exposure. Cold-shock proteins (RBM3) promote neural repair and synaptic preservation. The free anti-inflammatory that costs only discomfort.Mäkinen et al., Eur J Appl Physiol (2008) · Bhambhani et al., Arctic Med Res (1997)
⚠ Contraindicated: uncontrolled hypertension, Raynaud's, cold urticaria, severe cardiovascular disease. Avoid immediately after PRP/stem cell procedures (impairs engraftment via vasoconstriction). Numbness >5 min post-treatment = exposure was too long.
Provider Notes
Post-exercise or post-PBM for sequenced recovery. Pair with WBV same day for comprehensive non-pharmacologic performance protocol. The TCD Sustainable Super Focus Stack includes cold exposure as one of the highest-ROI daily interventions — free, builds grit, no tolerance.
Order from Peptide Pure →
WBV (Whole Body Vibration)
In-Clinic + Home
★★★☆
Duration
10–20 min standing · 3–5x/week
Frequency
25–40 Hz · Pivotal platforms preferred
Upper Body
Low amplitude
Lower Body
High amplitude for bone density
Mechanism & Evidence
NASA-developed for astronaut bone loss prevention. Vibration platforms (20–50 Hz) stimulate involuntary muscle contractions, lymphatic drainage, bone density, and independent GH release. WBV independently boosts GH — layering with GH secretagogues amplifies effect. Significant bone density improvement in postmenopausal women in multiple RCTs.Verschueren et al., J Bone Miner Res (2004) · Bosco et al., Acta Physiol Scand (1999)
⚠ Avoid with acute DVT, kidney or gallstones, recent implants, retinal detachment, acute fractures. Mild dizziness initially — use grip support.
Provider Notes
Combine with PBM post-session for multi-modal cellular stimulation. Pair with PEMF for bone density protocols. Add to GH peptide protocols — WBV independently stimulates GH, creating additive effect. Pre-cryotherapy for sequenced recovery. Excellent for elderly patients or those with limited exercise tolerance.
Order from Peptide Pure →
Frontier & Emerging
Plasmapheresis (Therapeutic Plasma Exchange)
Clinical Setting RequiredFrontier
★★☆☆
Standard
5 exchanges over 10–14 days
Maintenance
Monthly or quarterly
Setting
Clinical only — vascular access required
Access
Limited outside academic centers
Mechanism & Evidence
Therapeutic plasma exchange removes inflammatory cytokines, autoantibodies, senescent factors, and age-related proteins from circulation. Inspired by young blood parabiosis research — removes the pro-aging signals from plasma. Alkahest/Grifols clinical data: improvements in Alzheimer's cognitive markers after serial exchanges. Emerging longevity application on top of the established apheresis literature.Sha et al., Aging (Albany NY) (2019) · Pajonk et al., J Cereb Blood Flow Metab (2020)
Provider Notes
Combine with NAD+ IV post-exchange — the cellular renewal window after plasma clearing is the optimal time for mitochondrial loading. Add stem cells/exosomes during the reduced inflammatory burden window. HBOT amplifies regenerative response. High cost and limited access are the primary barriers. Consult with clinical team before recommending.
Order from Peptide Pure →
Focused Ultrasound (FUS / HIFU)
FDA-Approved (Tremor/Parkinson's)Specialized Centers
★★★☆
Low-Intensity
20–60 min · BBB opening (transient 6–24h)
HIFU
Single session · Tissue ablation
MRI-Guided
Real-time targeting required
Setting
MRI suite · Specialized centers only
Mechanism & Evidence
Non-invasive, image-guided focused acoustic energy with multiple applications. FDA-approved (Exablate) for essential tremor and tremor-dominant Parkinson's — ablates specific thalamic targets without craniotomy. Low-intensity FUS opens the blood-brain barrier transiently (6–24 hours) — revolutionary for neurodegeneration: allows delivery of Cerebrolysin, Dihexa, or antibodies to brain tissue that otherwise cannot cross the BBB.Elias et al., NEJM (2016) · Lipsman et al., Nature (2018)
Provider Notes
The BBB-opening application changes everything for neurodegeneration protocols. Sequence: FUS BBB opening → immediate IV Cerebrolysin or Dihexa → Semax IN for BDNF amplification. The 6–24 hour window is the delivery opportunity. Combine with stem cells/exosomes for targeted neural repair at the lesion site. Refer to specialized neuro centers.
Order from Peptide Pure →
Xenon Gas Therapy
Clinical Setting RequiredFrontier
★★☆☆
Concentration
25–30% xenon in oxygen mixture
Session
15–30 min inhalation
Frequency
1–3 sessions weekly
Barrier
Rare gas — expensive and limited supply
Mechanism & Evidence
Noble gas with neuroprotective, analgesic, and anesthetic properties at sub-anesthetic concentrations. Inhibits NMDA receptors (same as ketamine, without psychedelic effects) and upregulates HIF-1α, promoting tissue protection. No metabolism, no organ toxicity — truly pharmacologically inert except at receptor level. TBI/stroke research shows significant neuroprotection when administered early.Ma et al., Anesthesiology (2007) · Delphin et al., J Clin Anesth (2007)
Provider Notes
Layer with NAD+ IV for neuroprotection + mitochondrial support. Combine with transcranial PBM for neuroplasticity stack. Use in TBI/stroke recovery windows. Primary barriers: rare gas supply chain, specialized delivery equipment, and cost. Mild euphoria during inhalation is expected — counsel patients.
Order from Peptide Pure →
Bioelectric Medicine (VNS)
FDA-Cleared (VNS/Gammacore)In-Clinic + Home
★★★☆
Auricular VNS
15–30 min daily via ear clip device
Gammacore
Non-invasive cervical · Migraine/cluster
Implanted
Surgical — epilepsy/treatment-resistant depression
Target
Vagus nerve → NF-κB suppression via cholinergic anti-inflammatory pathway
Mechanism & Evidence
Targeted electrical stimulation of the vagus nerve to modulate inflammatory pathways, organ function, and immune response. FDA-cleared Gammacore for migraine and cluster headache. Implanted VNS for epilepsy and treatment-resistant depression. Transcutaneous auricular VNS: emerging data for PTSD, anxiety, inflammatory conditions, and autonomic dysregulation. Activates the cholinergic anti-inflammatory pathway — the nervous system's direct brake on systemic inflammation.Tracey, Nature (2002) · Pavlov & Tracey, Nat Rev Immunol (2012)
Provider Notes
Pair with Oxytocin nasal for vagal + bonding synergy — compound effects on social anxiety and PTSD. Layer with vibroacoustic therapy for multi-modal vagal stimulation. Use alongside KPV and Thymosin Alpha-1 in immune protocols. Transcutaneous VNS devices are home-compatible and low-risk. Excellent adjunct for patients with high sympathetic tone, chronic stress, or inflammatory conditions.
Order from Peptide Pure →
Vibroacoustic Therapy
In-Clinic + Home Devices
★★☆☆
Frequency
30–120 Hz via bed/chair/bone conduction
Session
20–40 min · 2–5x weekly
Gamma
40 Hz for gamma-wave entrainment (cognitive)
Home
Devices available for home use
Mechanism & Evidence
Low-frequency sound waves delivered somatically stimulate vagal tone, reduce cortisol, and entrain brain waves. 40 Hz stimulation drives gamma-wave entrainment — the same frequency disrupted in Alzheimer's and cognitive decline. Emerging data from MIT: 40 Hz sensory stimulation reduces amyloid beta in mouse models. Reduces HPA axis reactivity and enhances parasympathetic tone when used regularly.Iaccarino et al., Nature (2016) · Levin et al., Front Aging Neurosci (2019)
⚠ Avoid with active DVT, recent implants, vibratory urticaria, active fractures. May cause emotional release during sessions — prepare patients. Not appropriate during acute inflammatory episodes.
Provider Notes
Layer with PBM for multi-sensory neuroplasticity. Use pre-Selank/Semax for enhanced CNS receptivity to peptides. Combine with PEMF. Excellent for PTSD and anxiety patients alongside Oxytocin nasal. The TCD protocol includes daily 40 Hz exposure as a foundational cognitive longevity intervention.
Order from Peptide Pure →
Pre-Built Protocol Stacks

Clinical combinations.
Proven starting points.

Pre-built stacks from our IRB registry. Individualize based on patient labs, presentation, and response. Each is a framework — SHERPA generates patient-specific protocols from these foundations.

Repair
Wolverine / Tissue Repair
Tendon · Ligament · Post-surgical · Muscle
BPC-157500mcg SQ near injury 2x/day × 6wk
TB-5005mg SQ 2x/wk × 4wk → 2.5mg/wk
PRPIntra-articular series × 3, every 4 weeks
BPC-157 drives VEGF/angiogenesis at site; TB-500 accelerates systemic cell migration; PRP delivers concentrated growth factors directly.
Longevity
Anti-Aging / Longevity Core
Healthspan · Cellular rejuvenation
Epithalon10mg SQ daily × 20 days, 2x/year
NAD+ IM50mg 2x/week, ongoing
Rapamycin5mg oral once weekly, continuous
MOTS-c10mg SQ 3x/week × 12 weeks
CJC/Ipamorelin300mcg SQ nightly × 12 weeks
Epithalon elongates telomeres; NAD+ fuels sirtuins/PARP; Rapamycin activates autophagy; MOTS-c optimizes AMPK; GH peptides preserve body composition.
Metabolic
Metabolic Optimization
Fat loss · Insulin sensitivity · Body recomposition
Retatrutide1mg → 3mg SQ weekly (titrate)
Tesamorelin2mg SQ daily (visceral fat)
MOTS-c10mg SQ 3x/week
AOD-9604500mcg SQ daily, fasted AM
BPC-157 oral500mcg 2x/day (GI protection)
Retatrutide suppresses appetite + thermogenic fat burning; Tesamorelin targets visceral fat; MOTS-c activates AMPK; BPC-157 protects GI during GLP-1 titration.
Neuro
Neuroregeneration
Post-TBI · Stroke · Cognitive decline · Brain fog
Cerebrolysin10–30mL IV/IM daily × 20 days
Semax600mcg IN 3x/daily × 20 days
Selank400mcg IN 2x/daily × 20 days
BPC-157500mcg SQ daily × 6 weeks
NAD+ IM50mg 2x/week × 8 weeks
Cerebrolysin provides neurotrophic factors; Semax amplifies BDNF; Selank manages neuroinflammation; BPC-157 protects gut-brain axis; NAD+ restores mitochondrial function in neurons.
Immune
Immune Reset
Post-viral · Autoimmune · Chronic infection
Thymosin Alpha-11.6mg SQ daily × 4 weeks → 3x/wk
Thymulin200mcg SQ daily × 6 weeks + Zinc 30mg
KPV oral500mcg 2x/day × 8 weeks
IV Vitamin C25g 2x/weekly × 8 weeks
TA-1 restores T-cell function; Thymulin regenerates thymic capacity; KPV selectively quiets NF-κB; IV Vitamin C supports immune cells and acts as pro-oxidant at pharmacologic doses.
Cosmetic
Skin Rejuvenation
Collagen · Hair · Anti-aging · Inside + out
GHK-Cu topical2% daily + 1mg SQ daily × 8 weeks
PRP facialMicroneedling + PRP monthly × 3
Exosomes facialApplied post-microneedling
Epithalon10mg SQ daily × 20 days (biannual)
CJC/Ipamorelin300mcg SQ nightly × 12 weeks
GHK-Cu resets dermal gene expression; PRP + Exosomes deliver growth factors to dermis; Epithalon elongates fibroblast telomeres; GH peptides support skin turnover. Inside-out and outside-in simultaneously.
Enroll in IRB Registry → Generate with SHERPA →